A semi-truck was filled with 148 bags of clothing and 50 boxes of shoes, belts, purses and other items.
The church has been collecting donations since May.
MASTER Provisions, a ministry that helps churches collect and distribute clothing to areas in need, provided the semi-truck.
The clothes drive is part of the church's Missions-in-Action month.
The re-packing of clothes from donation boxes into shippable bags and boxes began on Saturday, and culminated Monday night.
First Christian Church had help from Boy Scout Troop 101 as well as The House of Hope.
"We couldn't have accomplished this today without the help of these groups and the members of the congregation who came out," project coordinator Brian Fagg said.
The clothes will be distributed in Honduras by a partner-ministry based in the country.
"Our hope and prayer is that these donated items from the community will make a difference in the lives of those Hondurans," said Fagg.