Members of the Senate Judiciary Committee approved the resolution Thursday.
Sen. John Waterman (R-Shelburn), supports the resolution, which passed by a vote of 5-4, with all Republicans voting in favor and the Democrats against.
The resolution now progresses to the full Senate for further consideration.
"Traditional marriage should be protected and Hoosiers should have the right to vote on this amendment," Waterman said. "Once again, it appears this resolution will be stopped by Democrats in the House of Representatives and that just isn't right."
In 2005, the Indiana General Assembly overwhelmingly voted in favor of the resolution, which officially declares that marriage in Indiana is defined as being between one man and one woman. In order for the resolution to become part of the state constitution, it must pass two separately elected sessions of the General Assembly and then be approved by a majority of voters statewide.
If the resolution is not approved by both chambers of the legislature this year, the process must begin again next year and the earliest the issue could be placed before Hoosier voters is 2012.
Nationwide, 27 states have passed constitutional amendments defining marriage. According to the resolution's author, Sen. Brandt Hershman (R-Wheatfield), today's vote was the 10th time this issue has been dealt with by the Indiana Senate either in committee or on the floor.
Waterman serves Senate District 39, which includes Clay, Greene, Knox, Daviess, Owen, Sullivan and Vigo counties.