ISP Sr. Trooper Chris Carter was called to the scene at approximately 11 a.m. for the rolled vehicle.
According to Carter, the driver, Zhe Meng, California, was driving eastbound on Interstate-70 near the 20-mile marker when the vehicle began to veer off the road.
Witnesses told Carter the driver of the semi-truck attempted to regain control and then drove off the road, causing the flip.
"It does appear like he had fallen asleep," Carter said. "The driver was able to escape the vehicle through the windshield, but he had a very bad head injury."
Carter wasn't the first person on the scene, however.
An EMT traveling westbound on I-70 witnessed the accident and pulled over to immediately assist the driver.
"He did stop, crossed the median and helped the driver," Carter said of the unidentified pedestrian. "He did what he needed to do. He did an excellent job. We don't see that very often."
Meng was airlifted to Wishard Hospital, Indianapolis, for further evaluation.
Carter said he believed Meng's injuries were not life-threatening.
"He was groggy, but he was talking to us," Carter said.
The semi-truck was carrying shoes, tobacco, beef jerky and various other materials that were not hazardous.
Meng's passenger, Qing Lee, was not injured. Lee said he was asleep when the accident took place.
After haulting eastbound traffic on I-70 following the accident, officials opened the left eastbound lane of I-70 at approximately 11:45 a.m.
Other agencies assisting at the scene included Transcare, Jackson Township Volunteer Fire Department, Posey Township Volunteer Fire Department, Air Evac and the Clay County Sheriff's Department.