Officials were dispatched to the 29-milemarker of I-70 at the Clay-Putnam County Line at approximately 8:18 a.m. for the accident.
According to Indiana State Police Public Information Officer/Recruiter Sgt. Joe Watts, it was reported a white Pontiac Grand Prix -- with an Ohio license plate -- was traveling eastbound on I-70 at a high rate of speed.
Two people traveling in the car were pronounced dead at the scene. The names of the victims have not been released.
Watts said the two victims were ejected from the vehicle. He added the driver of the semi complained of back pain, but refused treatment at the scene. He was released..
Traffic was stopped on I-70 temporarily, but one lane opened at approximately 9 a.m.
In addition to ISP, other agencies responding to the accident included TransCare, the Cloverdale Township Volunteer Fire Department, Clay County Sheriff's Department, the Clay County Coroner, Putnam County Operation Life, and the Reelsville Volunteer Fire Department.
This story will be updated as more information becomes available.