Timothy A. Cheatham, 44, Harmony, and Ronald Ingalls, 38, Poland, were both transported to federal authorities in Indianapolis this week.
Appearing in federal court on the allegation of distribution of methamphetamine in excess of 500 grams or more, Cheatham remains in federal custody pending further court proceedings.
Arrested earlier this month for operating a vehicle while intoxicated, Ingalls was also a person of interest in the investigation of alleged drug activities in Clay and Putnam counties.
Officials confirmed Ingalls was also in federal custody pending a case review on similar drug allegations Thursday.
Because federal authorities have showed an interest in the cases, Clay County Prosecutor Lee Reberger said his office would have to make a decision soon as to whether to drop local charges or continue with prosecution in the separate cases.
However, he said the federal government has greater resources to prosecute suspects more aggressively under federal law than individual state statues, which is why local charges are usually dropped to allow the federal courts to prosecute suspects to the fullest extent of the law.