The cuts began in January. Daniels, during a visit to Brazil Thursday, said the cuts were necessary.
"We've squeezed everything else so much harder," Daniels said. "It's one of those things that had to be done."
Daniels claimed during the first five years of his administration, education spending had been raised 12 percent.
He said the cuts shouldn't be "too much to ask."
"If anyone doesn't like it, ask 'what tax do you want raised,'" Daniels said.
Daniels pointed to the recent Indiana State Board of Education citizen's checklist, stating school districts statewide should look at it closely.
"There are 9-10 things (on the list) any district should do before reducing (teaching staff)," he said.
The list asks citizens to determine if their school district has "taken these actions to increase savings and efficiency."
Among the items on the checklist is refraining from "all salary and benefits increases for all school employees."
On Thursday, Daniels said -- across the board -- teachers' salaries are higher than the average Hoosier.
Despite the cuts, Daniels said Indiana is better off the most of the states in the Midwest.
"Our reduction here is so much smaller than other states," he said. "We had to do it and we're dealing with it."
Daniels said the state spends more per pupil than most states across the nation.
"We're way toward the generous end," he said. "There's only six or seven states that dig deeper than Hoosiers do. How much more can you dig?"
Daniels said the state "delivered more money" to school districts when it could, but some of that money was not spent wisely.
"When money gets wasted, children get cheated," he said. "Kids don't have as many opportunities."
Daniels added he didn't expect any more cuts.
"I hope not," he said.
While in Brazil Thursday, Daniels also touched briefly on the state's unemployment.
Recent statistics showed in December, the state's unemployment rate was 9.9 percent, which Daniels said was under the national average.
"We believe we've done everything we know how to make Indiana the most attractive place for jobs," he said, adding several jobs were added across the state before the national economy began to slip into recession.
"It felt like being the prettiest girl in school and they called off the prom," he said of the recession.
Daniels said job growth in the state would depend on the national economy.
"If we can hold on, other states will slip one more notch behind us," Daniels said. "I think we can do better than other states, but we need the whole economy to come back."