At approximately 6:50 p.m., firefighters with the Posey Township Volunteer Fire Department responded to the fire.
According to fire chief Larry Tempel, the driver, from Las Vegas, was able to get parked on the apron of the interstate and exited the cab of the vehicle without injury.
The vehicle was a total loss, but fire did not get into the interior of the trailer, which contained packaged vitamins and medicine.
A small grass fire was contained before it reached the tree line.
The fire closed off westbound traffic on I-70 for several hours. Tempel said one lane of traffic was opened up after about 30 minutes, but the wreckage wasn't cleared until 10:45 p.m.
Other agencies responding to the fire included the Jackson Township Volunteer Fire Department and the Indiana State Police.
The driver of the vehicle was not identified.