No injuries were reported from the crashes.
The vehicles entered the rest stop and lost control on ice.
Crews with the Indiana Department of Transportation were working on the conditions Thursday afternoon.
Other than that, ISP officials reported traffic conditions were under control despite ice on the roadways.
According to ISP officials, Interstate-70 was "mostly dry with a few scattered slick spots, running smoothly."
United States 41 south was "mostly dry with a few scattered slick spots in Vigo/Sullivan counties," and U.S. 40 east in Vigo County "is in good shape with a few scattered slick spots."
However, the post reported U.S. 40 in Putnam County "is still experiencing snow and ice covered slick spots."
In addition, U.S. 36 east in Parke County "has snow and ice slick spots," and State Road 63 in Vigo County is in "good shape with a few slick spots and in northern Vermillion County, a few more scattered ice/snow slick spots."
The post covers Parke, Vermillion, Vigo, Clay, Putnam and Sullivan counties.
The post also reported an ISP trooper's patrol car was struck at 7:30 a.m., Thursday, in eastern Indiana, but injuries appeared to be non-life threatening. As well, officials reported five officers in central Indiana (three troopers and two sheriff's deputies) were struck along the roadway while investigating other crashes.