The two students, Clay City Elementary's Nick Grasso, and Jackson Township Elementary's Kamryn Kikta, were honored after their drawings were chosen to be placed on billboards, warning of the dangers of smoking.
Health Department Educator Beulah Hofmann told The Brazil Times the process was a daunting task.
"We had some really good posters," Hofmann said. "It was hard to decide."
Grasso said he was unaware his drawing was chosen until his mother told him.
He said his mother was driving home from work when she saw his billboard.
"I was surprised," he said.
Initially, Grasso's billboard, depicting a snowman saying, "Smoking is not good," had been placed off U.S. 40. However, it has since been moved to the intersection of SR 46 and SR 59.
Nick, 11, is the son of Tammy and Gary Grasso. He is in Joanie Mitchell's classroom.
Kamryn found out about winning through her teacher, Dan Webster.
"My teacher said, 'Do you know what you've won?' I said no and he said I had won the billboard contest," she said. "I was really excited. I was really happy."
Kamryn's billboard encourages all to focus on music and not smoking.
Kamryn, 10, is the daughter of Tammy and Pete Kikta.
Both students also received a miniature billboard with their artwork and a T-shirt with their design.