Interstate-70 is currently closed in both directions between Cloverdale and Brazil.
At around 4:30 p.m., Indiana State Police reported a tanker truck crash with leaking hazardous material near the 30-mile marker.
Fire and police agencies, including hazardous material units from Cloverdale Township and Greencastle, have responded to the incident.
According to State Police dispatches, at least one person has died in the incident.
The Indiana Department of Transportation website estimates the highway will be closed between United States 231 and State Road 59 until after 11 p.m.
No further details have been released at this time.