Weather experts reported as many as 95 confirmed tornadoes touched down, destroying communities from the Great Lakes to the Southeast.
"Our hearts go out to everyone who has been affected by these severe storms this week," Wabash Valley Chapter Executive Director Carol Stevens said. "Our top priorities right now are making sure people have a safe place to stay, a warm meal and a shoulder to lean on as they begin to clean up their neighborhoods.
"The Red Cross is also working closely with our government and community partners to make sure everyone gets the help they need."
Friday night, the Red Cross opened or supported 22 shelters in Missouri, Illinois, Kentucky, Oklahoma, North Carolina, Alabama, Indiana, Ohio, Tennessee, Virginia and West Virginia.
Across the affected states, trained Red Cross disaster workers are mobilizing to begin feeding operations and distributions of relief supplies.
Red Cross health services and mental health workers also will be out in neighborhoods helping people cope with what they've seen and experienced.
And damage assessment teams will also help the Red Cross and partners discover the full scope of the damage.
Those willing to help people affected by disasters like tornadoes and floods, are encouraged to make a donation to support the American Red Cross Disaster Relief by visiting www.redcross.org, calling 1-800-RED-CROSS (1-800-733-2767), or texting the word REDCROSS to 90999 to make a $10 donation.
Contributions may also be sent to local Red Cross Chapters or to the Red Cross, PO Box 37243, Washington, D.C., 20013.
To access local Red Cross shelters, call local emergency officials, log on to www.redcross.org, or call 1-800-RED-CROSS.