Registration is scheduled to begin at 9 a.m., with runners beginning at 10.
Runners, walkers and waggers -- people who wish to walk their dogs -- are all invited.
Organizers are asking that all dogs be up to date on their shots and be social and friendly.
A "cat napper" division for people who cannot participate but want to help the shelter will also be available.
All entries received by April 15 will be guaranteed a T-shirt.
Late entries cannot be guaranteed a T-shirt.
Awards for 12 different age groups in each category will be given away.
Registration forms are available online at clayhumane.com, or may also be picked up and dropped off at Four Loving Paws Veterinary Clinic, New Elegance Salon and Spa and the shelter.
Registration forms may also be mailed to Rescue Run, Attn: Stacy Trusty-Dotson, 3025 Homestead Dr., Brazil, Ind., 47834.
Those wishing to sponsor the event are welcome to at a cost of $50.
All sponsors will be printed on the back of the T-shirts.
For further information, call Trusty-Dotson at 317-443-2918.